Eight weeks of treatment with cannabis oil caused a big reduction in Crohn’s illness symptoms compared to a placebo.
Cannabis oil can lessen pain and improve quality of life in patients diagnosed with Crohn’s disease, according to new research recently presented at the European Gastroenterology Conference.
Crohn’s illness may be a chronic inflammatory internal organ illness that affects the liner of the alimentary tract. Most common in adults 19-40 years, the disease can lead to abdominal pain, severe diarrhoea, fatigue, weight loss, and malnutrition.
To assess the effects of cannabis oil on Crohn’s disease, specialists in Israel used a randomized, placebo-controlled investigation involving 45 people with moderately severe cases of the disease. For eight weeks, the participants with either given cannabis oil or placebo. Their symptom severity, quality of life, and inflammation in the gut were measured before, during, and after treatments.
“Cannabis oil has been used for hundreds of years to treat a good vary of medical conditions, and comparisons have shown that several individuals with Crohn’s illness use cannabis oil frequently to relieve their symptoms,” said lead researcher Dr Timna Naftali, speaking at the conference. “It has invariably been thought that this improvement was associated with a discount in inflammation within the gut and therefore the aim of this study was to research this.”
Naftali and her colleagues found that subjects given the cannabis oil experienced a significant decrease in symptoms and a significant improvement in the quality of life measures compared to the placebo group. Sixty-five per cent of patients receiving cannabis oil met strict criteria for clinical remission after the eight weeks, compared to 35 per cent of the placebo recipients.
The study didn't reveal, however, any effects of cannabis oil on gut inflammation.
“We have antecedently incontestible that cannabis oil can turn out measurable enhancements in Crohn’s illness symptoms however, to our surprise, we saw no statistically significant improvements in endoscopic scores or in the inflammatory markers we have a tendency to measured within the cannabis oil cluster compared with the placebo cluster,” said Naftali.
“We apprehend that willnabinoids can have profound anti-inflammatory drug effects however this study indicates that the development in symptoms might not be associated with these anti-inflammatory drug properties,” she added.
Naftali and her colleagues said they intend to further investigate the potential anti-inflammatory effects of cannabis oil and its potential therapeutic application for inflammatory bowel diseases.
They specifically want to look into cannabis’ interaction with the endocannabinoid system, a major regulatory network responsible for regulating balance in an array of functions, including immune response.
“There are excellent grounds to believe that the endocannabinoid system may be a potential therapeutic target in Crohn’s illness and alternative gastrointestinal diseases,” said Naftali. “For now, however, we can only consider Rick Simpsons Oil as an alternative or additional intervention that provides temporarily symptom relief for some people with Crohn’s disease.”
Naftali acknowledged the small number of participants in her recent research and that “moving forward, larger and longer investigations are required.” The new study has not yet been published in a peer-review journal.
Cannabis and Crohn’s Disease
Previous findings have additionally shown cannabis to be effective for managing symptoms related to Crohn’s illness.
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