When one hears the term “Rick Simpson Oil,” a variety of core diseases and ailments come to mind. Cancer, HIV/AIDS, arthritis, induration, and Crohn’s disease all gain significant benefit from the cannabinoids and terpenes contained in cannabis. A set of diseases not generally conjured are those of the liver. Current research indicates that a lack of homeostasis (balance) in the body’s endocannabinoid system (what a medical professional would call “dysregulation”) can result in hepatitis, fibrosis, and cirrhosis.
Liver fibrosis, one of the most common forms of liver disease, afflicts more than 400,000 patients in the United States and is the tenth leading cause of death in the country. It happens once the liver, the largest organ in the human body, experiences “extreme growth of scar tissue” that results from chronic inflammation and the death of liver cells. Dying cells ar replaced by those who ar create, a process that produces abnormal areas of tough, fibrous tissue called nodules. As additional nodules kind, the liver begins to literally harden.
Cirrhosis is a condition in which the liver does not function properly, typically because of long-term damage. This harm is commonly inflicted throughout continual alcohol binging and suffered by alcoholics. Like Alzheimer’s, cirrhosis exposes itself very slowly, typically over months or even years. It may lead to patients being weak and tired and experiencing swelling of the calves and feet. They may conjointly exhibit yellow skin and bruise simply. One of the foremost dangerous symptoms of cirrhosis of the liver is that the accumulation of abdominal fluid, which may become very rapidly infected. Other possible outcomes include liver cancer and bleeding from the oesophagus.
Much media attention is paid to the problem of alcohol versus cannabis for recreational use. It is fitting will|which will|that may}nabis offers not solely a healthier euphoriant than hard liquor or booze however conjointly one that can facilitate repair the harm exacted on the body, especially the liver, by Associate in Nursing overabundance of the alcohol molecule — particularly over the long run. A variety of cannabinoids battle inflammation, which is the root cause of many diseases, including cancer, arthritis, fibromyalgia, and liver disease.
Endocannabinoid System and Cirrhosis
Many theorize that infirmities like cirrhosis and other diseases, especially those related to inflammation, are the result of an endocannabinoid deficiency, or essentially being malnourished in terms of cannabinoids and terpenes. Why? It turns out that victims with active cirrhosis feature CB2 receptors in their liver cells, whereas those not suffering from the disease lack these receptors. CB1 and CB2 receptors ar those targeted by cannabinoids like consciousness-altering drug and CBD. It is solely through the binding of those special molecules with the suitable receptors that medical profit is old by patients.
Is this expression of cannabinoid receptors, that is meant to cut back the pathology method, the pathologic liver’s means — via the endocannabinoid system and its governance of the system — to be ready to simply accept phytocannabinoids (those derived from plants like cannabis) with the goal of restoring health and homeostasis? Researchers have discovered just enough to understand that this mechanism is very similar to how cannabinoids take control of cancer cells, basically reprogramming them to cease spreading or even self-destruct.
It is interesting to observe how these CB2 receptors are located in the liver cells of patients with active cirrhosis, but not in those people not experiencing it. This research appears to indicate that the endocannabinoid system plays a protective role in a variety of liver diseases and overall immune system function.
Fibrosis and Consumption Volumes
Some considerations have shown that the volume of cannabis consumed by a patient or lifestyle user determines the efficacy gained. For example, a 2004 analysis research in France regarding the development of fibrosis in hepatitis C patients found a “high progression rate” for fibrosis in those who daily consumed both cannabis and 30 grams of alcohol. For those who consumed cannabis enough, however, no effect was found on the development of fibrosis (it neither increased or decreased).
A 2005 examination conducted at Hebrew University grad school terminated that endocannabinoids — the body’s own internally-produced cannabinoids that ar closely concerned in regulation of the system and nervous systems — help control things like vascular changes and the modulation of inflammation. In addition, it found these endocannabinoids to be critical to proper neurological function and helpful for those suffering from liver diseases like fibrosis and cirrhosis.
“Endocannabinoids seem to be concerned in many aspects of acute and chronic disease.”
Like many similar efforts, these researchers called for further investigations to better understand the role of both phytocannabinoids and endocannabinoids.
A 2011 analysis printed within the journal death and malady disclosed that CBD causes malignant cells in liver pathology to kill, a process called “induced apoptosis.” The research concluded: “Collectively, these results, coupled with the excellent safety and tolerability profile of cannabidiol in humans, strongly suggest that it may have great therapeutic potential…” The researchers recommended that THC may be an effective treatment for:
“…diabetic complexities, and perhaps other cardiovascular disorders, by attenuating oxidative/nitrosative stress, inflammation, cell death, and fibrosis.”
A study printed in 2013 within the journal Clinical communicable disease disclosed that counter to different studies, just like the 2004 French analysis cited on top of, regular cannabis consumption doesn't accelerate the progression of liver disease, specifically fibrosis. This comprehensive human study included nearly 700 participants and almost 2,000 person-years of follow-up.
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Tags: Health, Liver