Chemicals in marijuana may reduce the impact of stress-related disorders on the brain, according to recent conclusions out of Israel.
Suffering from stress will impair learning and memory skills. But researchers at the University of Haifa, led by Irit Akirav, PhD of the Department of Psychology, were able to diminish many of these impairments using synthetic cannabinoids in rat models of chronic stress.
Two of their studies were recently printed within the journal Neuropsychopharmacology.
In the initial study, rats were exposed to chronic restraint stress daily for 2 weeks, with the synthetic cannabinoid WIN55,212-2 being given to one group of animals at the end of every day. Cannabinoid treatment was able to scale back the negative influence of stress on immediate memory and long synergism – vital learning and memory mechanism of the brain.
The second research, published just last week, found cannabinoid prescription effective in reversing impairments from stress-related depression. Using WIN55,212-2 again, the specialists observed a reduction in memory impairments as well as various symptoms of depression (including behavioural and weight changes) in a rat model of chronic mild stress.
In each sets of experiments, the CB1 pathway seemed to be responsible for the protection. CB1 receptors ar found in high concentrations within the brain and also are activated by psychoactive substance in marijuana.
While more investigation is needed, Dr Akirav and her colleagues conclude that cannabinoid activity could be a “novel approach to the treatment of cognitive deficits” that accompany “stress-related depression” and other “stress-related neuropsychiatric disorders.”
The investigations were printed before print and received funding from the Israel Science Foundation and therefore the Hope for Depression analysis Foundation
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Tags: Anxiety, Depression, Stress
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