Monday, 18 February 2019

The Endocannabinoid System: A Short Overview



The endocannabinoid system is a biological system which executes many important roles in the human body. It is also efficient for the physical and psychological effects of cannabis.

Specialists first learned the system while trying to understand the effects of cannabis and named it the endocannabinoid system for this reason. Endo attains for endogenous, which means originating within the body. Cannabinoid refers to the group of composites that activate this system.

What are Cannabinoids?
Cannabinoids are the artificial carriers for the endocannabinoid system. While many different cannabinoids survive, they all fall under two classifications: endogenous or exogenous.

Endogenous means originating inside the body. Also acknowledged as endocannabinoids, these aggregates are composed naturally by the human body. They associate with cannabinoid receptors to coordinate basic functions including mood, memory, appetite, pain, sleep and many more.

Exogenous means originating outside the body. The cannabinoids found in marijuana, such as tetrahydrocannabinol (THC) and cannabidiol (CBD), are contemplated exogenous. When applied, they also associate with cannabinoid receptors to generate physical and psychological effects in the body.

What are Cannabinoid Receptors?
Receptors are intelligence receivers. Messages come in the form of artificial messengers necessary to the receptor. These messages provide a characteristic effect within the body.

The endocannabinoid system has both receptors: CB1 and CB2. Each receptor reacts to different cannabinoids, but some cannabinoids can cooperate with both.

The administration of CB1 and CB2 receptors inside the body and brain illustrates why cannabinoids have certain effects.

CB1 receptors are found everywhere in the body but are frequently present in the brain and spinal cord. They are localised in brain regions linked with the behaviours they influence. CB1 receptors are also found in nerve endings where they act to lessen sentiments of pain.

CB2 receptors serve to be found in the peripheral nervous system. They are particularly concentrated in immune cells. When CB2 receptors are stimulated, they work to reduce inflammation. Inflammation is an immune response which is thought to play a role in many diseases and conditions.

With regard to the cannabinoids found in cannabis, specialists have found that THC connects to both CB1 and CB2 receptors, stimulating them just like an endocannabinoid.

Uses of the Endocannabinoid System
The endocannabinoid system is concerned with regulating many basic functions of the human body, including:

·       Appetite    ·       Inflammation
·       Metabolism    ·       Neural development
·       Pain    ·       Neuroprotection
·       Sleep    ·       Cardiovascular function
·       Mood    ·       Digestion
·       Movement    ·       Reproduction
·       Temperature    ·       Neural development
·       Memory and learning   


Besides managing basic functions, the endocannabinoid system also acts in acknowledgement to illness.

For instance, tumour cells have been proved to express more cannabinoid receptors than healthy cells. Comparisons also show a rise in endocannabinoid levels in patients with several disorders, such as Parkinson's disease, anxiety, chronic pain and arthritis.

As a result, some specialists consider the overall function of the endocannabinoid system is to coordinate homeostasis.

Homeostasis is a key factor in the biology of all living things. It is best characterised as the ability to maintain stable internal conditions that are necessary for survival.

The disease is mainly a result of a failure in producing homeostasis. Thus, the endocannabinoid system’s role in sustaining homeostasis makes it a unique and promising target in medicine.



 Disclaimer: the principles contained here is not designed nor meant to be a substitute for professional medical advice, it is only achieved for educational confidences only. You should recognise full responsibility for the way you decide on to use this information.

Tags: Endocannabinoid System

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