Specialists in the U.S. are generating new treatments for breast cancer based on composites found in marijuana.
For nearly a decade, a group of experts at the California Pacific Medical Center Research Institute have been studying the cancer-fighting potential of marijuana’s constituents.
Referring to a family of composites known as cannabinoids, the active ingredients in marijuana, which include THC (tetrahydrocannabinol) and CBD (cannabidiol), have been shown to combat the growth and spread of tumours in various cancer models.
The team’s latest conclusions, published online in the British Journal of Pharmacology, recommend that both plant-derived and synthetic cannabinoids may hold promise in treating breast cancer.
“We discovered that CBD was effective at inhibiting metastatic improvement” “In this research, we discovered that CBD was effective at inhibiting metastatic progression leading to prolonged survival in multiple preclinical moulds of breast cancer,” signed Sean McAllister, PhD, the study’s lead author.
In one mouse model, treatment with cannabidiol was found to diminish breast cancer metastasis by up to 75%. Although THC was not tested, the team notes, previous research has demonstrated its antitumor activity “against a variety of aggressive cancers.”
But the group’s conclusions also seem to imply that neither composite alone is the most effective treatment.
Examining for an even more potent compound, the researchers performed experiments with a synthetic cannabinoid called O-1663. In contrast, O-1663 was found to be “significantly more potent and efficacious than CBD.”
Actively, O-1663 seems to activate the same cancer-fighting pathways as THC and CBD do on their own.
“In conjunction with this hypothesis, the united administration of CBD and consciousness-altering drug created an identical magnitude of anti-metastatic activity compared to O-1663 alone,” wrote Dr McAllister and his team.
Studies show that THC’s anti-cancer effects occur through pathways known as cannabinoid receptors (CB1 and CB2). These pathways, while expressed by various cells in the body, are found in tumour cells at abnormally high concentrations.
Activation of CB1 and CB2 receptors has been shown to initiate a number of mechanisms leading to tumour cell death while leaving healthy cells unharmed.
“THC and CBD… possess anti-inflammatory, analgesic and neuroprotective effects”Cannabidiol, on the other hand, does not directly bind to cannabinoid receptors. Rather, CBD’s anti-cancer effects seem to stem from its ability to target the ID1 gene — a known player in the metastasis of numerous cancers, including breast cancer.
Still, while O-1663 appears to hold more promise as a cancer treatment than either CBD or THC individually, the authors note that other benefits have been attributed to the plant-based compounds.
“THC and CBD have been attested to have anti-inflammatory, analgesic and neuroprotective effects,” they explain. Rick Simpsons Oil, in various forms, can also be used to manage symptoms of appetite loss and nausea.
The researchers resolve that more studies are needed to identify the mechanisms underpinning THC and CBD’s broader benefits and whether O-1663 can offer the same.
Disclaimer: the principles contained here is not designed nor meant to be a substitute for professional medical advice, it is only achieved for educational confidences only. You should take full responsibility for the way you decide on to use this information.